Trade Link Buff Store

Item	B/O	Screenshot	Tradeable
Knives
St Talon Knife Marble Fade Fn 0.007	8000 rmb	SS	6.Jun
St Bayonet Autotronic Ft	4050 rmb	SS	15.Jun
Bowie Knife Scorched Ft 0.20	800 rmb	SS	31.May
Gloves
Specialist Gloves Crimson Web Mw	6000 rmb	SS	5.Jun
Broken Fang Gloves Yellow-banded Fn 0.062	5000 rmb	SS	6.Jun
Skins
AWP Graphite Fn w/ Fnatic Kato 14	1850 rmb	SS	06.Jun
USP-S Kill Confirmed Fn	1450 rmb	SS	06.Jun
USP-S Kill Confirmed Fn	1450 rmb	SS	06.Jun
M4A1-S Decimator Fn	90 rmb	SS	yes
USP-S Blueprint Mw 0.08	72 rmb	SS	yes

Prices are not firm! Im mainly interested in Item or Buff trades!
Buff Store
Add me on steam
Trade Link

I’m currently listening to the game’s soundtrack while studying and it makes my heart flutter with melancholy. Makes me reminisce on my first playthrough, not knowing what’s in store and how this soundtrack really resonates with me ever since 😢 it’s definitely a game I have to play at least 3 times a year.

I'm a British citizen who has been basically stranded in the Philippines for two months now. In that timespan, i've slept in a convenience store and just managed to secure myself accommodation for the month. I have a lack of funds therefore struggling to provide myself with food, only just getting by.
I have tried contacting the embassy and they've been no help! not only that, but my bank account has closed down because Emirates charged me TWICE for my plane ticket, sending my account into overdraft, therefore I can't even access any funds going into that account. I don't have any family that can help (they're all struggling financially) nor any friends that could help out. I don't think I'd be able to get a loan, lacking the credit to do so, otherwise I would have taken a loan no matter the interest and reaped the consequences of taking one.
I'm desperate and I miss home.
I would welcome any donation at all
If you need proof on my current situation I can provide you with what ever you need!
thanks for hearing me out, have a good day.

i’m moving to the dc area in about a month or two. i’ve been at my current salon for three years now, and while the environment in our salon is pretty nice, i’ve heard horror stories of other salons. i am very nervous about transferring & ending up in a salon with a toxic environment. just wondering if anyone here works at a store in dc or va that could let me know how it is there ?

Hi,
I've tried the Huel RTD Vanilla last week, and I thought I would order the Huel Black as the RTD in the store tasted amazing. However, I was quite disappointed to find that the Huel Black doesn't taste nearly as good as the RTD version. Did I perhaps order the wrong package or is there something else I'm missing here? Any insights or suggestions would be greatly appreciated. Thank you in advance!

Ok firstly to defend myself, the teacher deserved it , ok lets do the storyyy
Its Monday 5th , 2015 , i am nearly done high school and im getting .REAL. jordans in a few months so i was very excited but then out of nowhere my idiotic little teacher cum's towards me and says i got a E- on my grade, so reasonably i say "BITCH I WORKED HARD FOR MY GRADE YOU CUNT!!!!!!" , the teacher then says hes gonna get me suspended so i ran tf outta there , the school gave my mum a phone call saying im expelled now, so my mum says im not getting the jordans no more, then out of anger i flush her credit card down the toilet..A few days later i come up with a PERFECT plan, i decided to plant exactly 5 bombs in the school staff room, but first i had to search up "how to make boom boom bam's" in safari and it worked!!! , on friday i planted the bomb's in the staff room and ran away, i detonated them as soon as i left the school, over 69,420 people got caught in the explosion!, only 69 died tho :((((, i then found out bombing place's is illegal so i fled the country and started a new life in canada.
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I'm sorry this is long, I just haven't been able to get this off my mind and I don't know who to talk to about this, and I've been listening to some really sad music and its all I've been able to think about because of it. I'm sorry but I'm going to tell you my long story with a friend of mine.
I'll call her A, we met in a friend group, we've been friends for a while now, maybe about 2 years or so, her and I have been really close, essentially best friends. We used to spend nearly every night together and send pictures of things we were doing and do silly things and cute things and those things I'd imagine in romance movies. She was the first girl i really liked, too, and probably not a good sign. We always said goodnight to each other, we'd send pictures of sunsets and sunrises, we sat in silence enjoying each other's company, we played games together and spent lots of time together and were always open to one another, giving reassurance, comfort, and a listening ear if we ever needed one another. All of the nice things, i associate with her. I really love her. She's a wonderful person. Whenever she got jealous or upset, I reassured her that she was still an amazing person.
But she ended up liking me and another one of her friends, long story short, she chose him over me, she spent time with him while deciding on if she wanted him or I, which just felt like an extra punch to the face, and then he invited me to talk with his friend group and it felt like egged me on by saying A would be there. I hated that. I hated that I knew she would pick him over me, I felt so helpless in those few weeks I waited, I felt annoyed that I had to ask her if she made a decision when it felt like it was already made. But I feel guilty for those things, too.
She still wanted to be friends, and I said I did too, because I did, and I wanted to make it work. We didn't really talk for a bit, but she always came back to say she still wanted to be friends and that she didn't want me to leave our friend group. I decided to distance myself and take time for me. Which felt nice, and eventually, I felt a little bit more comfortable to be in our friend group after a while.
she messaged me every now and then that she missed us hanging out. She missed how we used to spend time together at night, or talk about things or just hang out. Which made me upset, I never expressed that with her, I just said I agreed because I did agree. But it felt unfair that she wanted things like this after she chose him over me. it never felt fair to me.
This has happened a few times, where a friend of ours I talk to, we'll call her B, I have some time with her and we enjoy talking and playing games together and hanging out. And Friend A gets jealous of that, I remember a few nights, I called her, and she was crying because she was upset because she thought I'd forget about her and she was scared of losing me because I was spending time with Friend B and was having fun. I felt bad about it, so I comforted her and reassured her I still like spending time with her because I do, I apologized, and she felt guilty about it. I told her I still valued her, and she told me she valued me a lot, too.
This doesn't feel fair to me, I can't become closer with my friends in our friend group, and I just want her to be happy no matter what, I don't want to disrupt her relationship. She wants us to talk like we used to, and she says how she still thinks of me and misses us. I don't want there to be conflict with her and her boyfriend, i don't want her to feel upset or jealous, I just, ahh I don't know, I DON'T KNOW I feel so stressed, and stuck. I still believe she's a good person because she still cares about me and our friends. She's still kindheared and wonderful. I don't want to leave our friendship behind, not friend A or friend B.
I guess TLDR, a friend of mine we used to like each other, she chose him over me, we still wanted to be friends, but i wanted to take time to myself for a bit. She missed me and the things we used to do, we stayed friends, I came back to out friend group, she got jealous and upset of my friend and I spending time together a few times, I reassured her I still like spending time with her, and she said how she misses us. And I feel lost. something like that, I'm sorry if this was a bad TLDR.
I'm sorry this is so long, and if this is disorganized or doesn't make a lot of sense. I just needed to let this off my chest. I'm sorry if it doesn't make sense, I'm sorry I keep saying sorry.

Okay guys, I'm using a throwaway cause my girlfriend seems to know a lot of people. Sorry, if it's a bit long and winded. Please bear with me.
My girlfriend (Jennifer; not real name) and I are both college students in a mostly white university. It's known for having a great engineering program and thus has an influx of brown South Asian students including me (Mostly male) come in.
Now, I am a Christian Indian born and raised in America, who comes from the stereotypical, traditional family who came to this college for engineering. My girlfriend is white who was apart of a sorority when she started college here for about 2 years until she had to leave due to time commitment issues. I met and started dating her about a year and a half ago when she was in the process of leaving. I had actually started liking here before I knew about her sorority past. (Just putting that out there)
Jennifer still keeps in touch with her sisters and also knows many guys and is still very social. I, on the other hand was nothing like her at all. She is the first girlfriend that I have had. I, like most brown guys it seems, was a shy, socially awkward nerd who didn't know how to talk to girls in the first year. I met a "friend" in one of my classes who seemed to gravitate towards me because I guess he knew I would be willing to help him out in class and help him with homework answers and perhaps he may have used me. I didn't care, because I was willing to do anything to make friends. In return, he invited me to hang out with him and his friends and in a short amount of time he taught me a lot of things when it came to the social scene, parties, clothes, and talking to girls. (I actually was able to get a hand-job from a girl who did it through pity for the most part)
Eventually, I met Jennifer at a party that my friend invited me to. We hit it off and we started dating. Everything is swell. She introduced me to her friends who didn't mind me at first. I introduced her to my friends both white and brown. I still made friends with the brown guys because that's my people, if that makes sense and helped them with their social life.
Now, this happened a few days ago and I haven't seen my girlfriend in person yet. Well, we were both talking about a Greek hosted party that we were invited to and encouraged to invite anyone we could. So, me being a friend wanted to invite a few of my brown friends to the party just as she wanted to invite her own friends. When my gf heard that I was going to invite other brown guys, she came up to me and asked me nicely "Is it alright if you didn't invite your friends?
I asked her why? She said "not all of them, just a few." I asked again which ones? She basically listed off all of my brown friend and none of the white friends that I was planning on inviting. (My list isn't that big btw). We went back and forth about it until she dropped this bomb.
"Well, let's be honest you went up a notch socially since we've been dating. You don't see Indian guys dating white girls like me at all do you? I did agree with her on that part regretfully. My girlfriend is a very hot and attractive girl like most sorority girls and does have guys eyeing her. I guess I agreed, because honestly every brown guy that I have seen with a girlfriend has been either overweight or just not attractive at all and I assume they are settling for a brown guy because no other guy will take them. So, I felt like the luckiest brown guy in the world since dating my girlfriend. I know this makes me a douche bag and I hate the fact I think like this and it doesn't help that Indian men are the least desirable by most women including Indian women :/
Anyways, I told her so are you dating me for some exotic thrill, pity, dare, or because you actually love me? She said "of course I love you. I wouldn't be with you with this long if I didn't". After, some loving words, we had sex and she went back home and we left the question about the friends up in the air. The party isn't for nearly 2 weeks, so there's time.
Now, I don't what to think or position to take from this exchange. On one hand, I feel very hurt emotionally as I could never measure up to my girlfriend especially when another dude could snatch her up easily. I'm also hurt because I am not ashamed of my heritage and should never be, but my girlfriend goes and says this. I love her so much and she may be my first everything for the most part, but I feel so close and understand one another on the same wavelength. I don't know if this could be get in the way of our relationship.
Tldr; My white girlfriend says that I should be lucky for dating her as a brown guy after getting into argument about inviting brown friends to a party and now I don't know how to feel about this and where I should I go from here.
EDIT: Thank you everyone for all of the advice and encouragement I received from you all. I decided I'm going to talk to my girlfriend and ask her about where she sees us in the future. I will also go more in depth for her reason for dating me and her views on brown people. I will make sure I update you all. It'll either be good or bad. I'll let you all know either way.

So my friend was telling me about some new game, and I forgot to ask what it was called and can’t wait to hear back lol.
I know most DND is played online with webcams and all that good stuff. But he mentioned some new game where it was all completely digital. Like a 2d map with 2d figures and everything is done on the computer, with no figures or physical objects
Obviously that’s not going to be nearly as fun as with figures and maps, but it’s something. Anyone know what I’m talking about or am I just really high?

I'll go first
My dad was just picking up something at the store when it came out, he was in line waiting, when he got to the front he was asked if he wanted a copy of the game with his item because they had a couple non pre ordered disks, so he bought it and downloaded, so me and my dad got it day one (I had to go so I wasn't able to play it until a week later)
Was a fun time

I have 20b/4k on bang didn’t think I’d have to add that but someone msg’d me & brought it up so.
I’m looking for multimasters as I’ve been masters in s14/15/16
I want to gain anywhere from 8-10k LP daily & high KP top 5’s will do that, especially when you’ve ran down the lobby & are warmed up for constant team fighting
I know in the current system it caters towards placement over KP but I’d rather have a top 5 finish with 15-20 kp than top 3 & under 10 kp.
I want to play an Agro comp, im best on Bang & in a fragger co/igl role.
I prefer a Bang/Horizon/Seer in this current meta but whatever you’re comfortable with. ( if we run this comp playing neaon your horizon even if whoever plays horizon is a fragger is the way to go) I also prefer to co/call/igl with whoever plays seer as their info as seer is important while I on bang co call as well as frag with horizon.
My PSN/Apex in game name is “Bluntvibezisaac”
Let me know your usernames & when you added me & I’ll get back to you.
My ideal time for playing is 7/8 pm CST to 2/3 AM CST
I’m going to hit 5k+ kills on Bang this season & also want to hit & maintain pred by end of the season.

My partner is really struggling to find a job. Lots of job postings on LinkedIn or Indeed seem promising but then lead nowhere. We’re both freelancers (I do design, he does writing) but we’re not able to support ourselves. I managed to get a retail job (with great luck) that’s 4 days a week so it allows me to do continue freelance work on my days off. We both went to film school but jobs in the industry seem impossible to get unless you’re connected. Any advice on how he could get a part time job? He tried applying on iStore’s vacancy site but it also doesn’t seem to lead anywhere.

The dog was barking at her husband's frantic attempts to extinguish the toaster, but Lulu was determined to have a productive, happy day. God help her. She was fiercely writing a grocery list.
"How do you stop spelling "bananas"?! She yelled in frustration as her husband passed by on his way out the front door with the flaming toaster.
"Where were you when that song came out?!" He yelled as he made a hasty exit.
"This shit is bananas..." she murmured to herself until she got to the spelling instructions, punctuated by the beat of her husband trying to smother the toaster fire with a shovel outside. She heard her neighbors talking to him. Great. Well, maybe this would stop them from gossiping about the Christmas Lights Incident anymore.
Her son called and said that he and his wife couldn’t come to lunch because the bus had turned into a spaceship, and there was just no way the driver was qualified to fly it. She told him that marijuana was illegal, but he said that he already knew.
Her husband left for work. She walked to the grocery store down the street ferociously, each step stomped with such energy that she scared the homeless people. No matter what happened, there was going to be corned beef and cabbage, damn it. And a completely unreasonable quantity of mint chocolate chip ice cream, because it was on sale.
She returned to find a sternly written warning from the Home Owner's Association taped to the front door. This happened a lot. She wasn't 100% clear what rule the toaster fire fell under, and apparently, the HOA board wasn't, either. If they had been, it would've been another fine.
Someone called her 11 times in a row, but she got dinner in the crock pot. By the time she picked up, her husband said that the doctor was sure his finger could be reattached.
"Don't worry about waiting around the hospital. The surgery will take hours," he said. Nevertheless, she first prepared herself through a generous application of her hot pink sparkly tactical blush, then went to the bus stop.
A disheveled young man tried to rob her on the bus, but she told him she didn't have time for that crap today. She recommended a good community college program that had helped her nephew get a fantastic job working with computers. He was so confused that he just got off at the next stop. He would forever remember it as the day a hooker turned his life around.
Three days later, she and her husband arrived back home with all their fingers. The neighbor she had texted had put out enough food and water for their dog to last a month, Lulu was relieved to see. She'd worried about that hyper little fluff ball. They could smell burned corned beef before they even opened the door. The house was as foggy as a speakeasy, so Lulu aired it out. She scrubbed the crock pot for ten minutes.
She prepared them two bowls of mint chocolate chip ice cream for their next meal.
"This is kinda fun. I like this better than if we'd had that corned beef," her husband chivalrously declared.
She laughed, simply happy that he could hold a spoon at this point.
"You know, I do, too."

Hello Dear community,
I need your help, or, at least I think I do. I've come into a point in the game in which I don't know how to go further. I'll explain; I have gear level 32 (with my special copper mace equipped). I play in a PvE singleplayer world with me myself and I. At this moment, I've killed several V blood targets;

• Alpha wolf
• Rufus the foreman
• Keely the frost archer
• Errol the stonebreaker
• Goreswine the ravanger
• Grayson the armourer
• Lidya the Chaos archer

Right now, when I look at my goals, I need to create a Castle Throne, which needs Iron. Another Goal I can set myself is upgrading the Castle heart, which needs glass.
Now it feels like both Iron and Glass are resources which are way out off my league still, with only an equipment level of 32. However, with some smart play, and using wolf form, I was able to sneak near the Iron mine and harvest some Iron. However, for me to be able to create Iron ingots, I need to kill Quincey the Bandit King, which is level 37, a long way from my level 32.
Any tips on how to proceed? Which steps should I take to have a better shot at getting Glass and Iron? Everything felt balanced up until now, but now I feel like a weak little vampire baby.
Thanks in advance!

Hello
I've recently come across this community and it has compelled me to do a significant amount of self-reflection. It didn't necessarily offer me new revelations, but it provided the final push I needed to acknowledge an inconvenient truth: I have been wasting my time gaming.
I have struggled with depression this past school year, and I've used video games as a crutch, despite knowing they don't provide any real relief. Too often, I've found myself neglecting my studies to play games for hours on end. The most troubling part is that I'm not even enjoying the time I spend gaming. There's a constant nagging thought in the back of my mind telling me I'm wasting precious time and falling short of my potential.
However, what really lit a fire under me and sparked my desire to quit gaming entirely was my girlfriend. We've been together for nearly six years, and she's truly phenomenal. We share dreams of a future together and she does so much to help me succeed and reduce my stress. This allows me to focus on my university studies and work towards securing a job that can support us both. But when I play video games, I can't help but feel I'm not holding up my end of the bargain. It's struck me hard: why am I wasting time on games when I could be advancing my studies and securing our future?
I am resolved to change, not only for my own sake but also for the love of my life. I want to give her everything she deserves and more, and I know I can't achieve that by squandering hours each day on something that ultimately doesn't matter.
I am truly grateful to have found this subreddit. Moving forward, I'm considering posting regular accountability updates here.
Sorry if this post seems a bit scattered. I've spent most of the last day gaming, it's almost 4 am now, and I'm dreadfully aware of how much I've set myself back for tomorrow. But, this serves as a reminder of why I must change. And I am committed to doing so, for myself and for the woman I love.

I'm building a pc to use it as media server in my house.
I already chose i5 3.4gh cpu, 32 RAM.
I bought 64gb SSD for the OS which gonna be windows.
Now I want to store some movies, so I'm searching on harddisk around 4tb, but I'm not sure what kind of harddisk should I choose?
I want something not expensive, I found seagate bluefox but 10tb, and it says it ment for NAS server.
Can anyone help me please? I don't want to buy the wrong harddisk

Hello fellows, familia. Grab a coffee/joint/gamersupp.
This is just a public health awareness thread about some little known things amongst the normans. Reddit wont let me post links, but what I will do is post study title and authors/year, and some cases abstract copy paste. I will do at the bottom after the statements.
So, as you all know, COVID is a thing still, and many didn't actually know what it was capable of, outside of comparisons to other coronaviruses and the acute illness. Right now, acute illness is incredibly manageable, but the long term effects on organs is becoming alarming, even in mild cases. So lets take it from the top, so we are on the same page. We will start on organ systems and virus character.
So, covid is pretty much a vascular virus, which seems to disrupt vasculature. Lets start before vaccines to demonstrate to those among us suspicious that the vaccine is the cause. (Its fine to worry about tech, i dont judge).
Every person in Sweden diagnosed with COVID-19 from Feb. 1, 2020, to Sept. 14, 2020 — a total of nearly 87,000 people. Their median age was 48, and 57% were women. Researchers compared them with more than 348,000 Swedish people of similar age and sex who did not have the virus.
In the week after a COVID-19 diagnosis, the risk of a first heart attack increased by three to eight times. The risk of a first stroke caused by a blood clot multiplied by three to six times. In the following weeks, both risks decreased steadily but stayed elevated for at least a month.
Thats PRE vax. In a population which probably have the obesity % of the US and a healthy hiking and outdoor culture. US obesity rate is 40%+. Sweden perhaps half or less. Also, viral load on exposure can be a large determination of severity acutely, but perhaps also viral creep inside the body and the resulting dysfunction and damage.
​
Risk of Cardiovascular Events after Covid-19: a double-cohort study Objective To determine absolute and relative risks of either symptomatic or asymptomatic SARS-CoV-2 infection for late cardiovascular events and all-cause mortality.
Conclusions Either symptomatic or asymptomatic SARS-CoV-2 infection is associated with increased risk of late cardiovascular outcomes and has causal effect on all-cause mortality in a late post-COVID-19 period
Characteristics of a COVID-19 Cohort With Large Vessel Occlusion: A Multicenter International Study

CONCLUSION:

COVID-19 was an independent predictor of incomplete revascularization and poor outcomes in patients with stroke due to LVO. Patients with COVID-19 with LVO were younger, had fewer cerebrovascular risk factors, and suffered from higher morbidity/mortality rates.
Long-term cardiac pathology in individuals with mild initial COVID-19 illness
In this cohort of selected previously well and home-isolating individuals initially evaluated at a median of 109 days and followed-up at 329 days after diagnosis of COVID-19 infection, respectively, the ongoing cardiac symptoms were related to mild but notable imaging findings, suggesting inflammatory cardiac involvement. At baseline, participants with cardiac symptoms had higher mapping values, suggesting diffuse myocardial inflammation, and more frequent pericardial enhancement, suggesting pericardial inflammatory involvement compared to asymptomatic participants. At follow-up, 53% of the cohort had persistent cardiac symptoms, whereas new symptoms developed in 5%.
Transcriptomic profiling of cardiac tissues from SARS-CoV-2 patients identifies DNA damage
In this study, we investigated the host transcriptome landscape of cardiac tissues collected at rapid autopsy from seven SARS-CoV-2, two pH1N1, and six control patients using targeted spatial transcriptomics approaches. Although SARS-CoV-2 was not detected in cardiac tissue, host transcriptomics showed upregulation of genes associated with DNA damage and repair, heat shock, and M1-like macrophage infiltration in the cardiac tissues of COVID-19 patients. The DNA damage present in the SARS-CoV-2 patient samples, were further confirmed by γ-H2Ax immunohistochemistry.
In comparison, pH1N1 showed upregulation of interferon-stimulated genes, in particular interferon and complement pathways, when compared with COVID-19 patients. These data demonstrate the emergence of distinct transcriptomic profiles in cardiac tissues of SARS-CoV-2 and pH1N1 influenza infection supporting the need for a greater understanding of the effects on extra-pulmonary organs, including the cardiovascular system of COVID-19 patients, to delineate the immunopathobiology of SARS-CoV-2 infection, and long term impact on health.
​

Great article by British Heart Foundation.

Is coronavirus a disease of the blood vessels?

Updated 12 May 2023
Dr Phoebe Kitscha explores how and why Covid-19 affects the whole circulatory system, and the research that is trying to tackle it.
​
March 27, 2020

Potential Effects of Coronaviruses on the Cardiovascular SystemA Review

'Coronavirus disease 2019 is associated with a high inflammatory burden that can induce vascular inflammation, myocarditis, and cardiac arrhythmias. Extensive efforts are underway to find specific vaccines and antivirals against SARS-CoV-2. Meanwhile, cardiovascular risk factors and conditions should be judiciously controlled per evidence-based guidelines.'
​
2022
Long-term cardiovascular outcomes of COVID-19
our results provide evidence that the risk and 1-year burden of cardiovascular disease in survivors of acute COVID-19 are substantial. Care pathways of those surviving the acute episode of COVID-19 should include attention to cardiovascular health and disease.
Acute and postacute sequelae associated with SARS-CoV-2 reinfection
The evidence shows that reinfection further increases risks of death, hospitalization and sequelae in multiple organ systems in the acute and postacute phase. Reducing overall burden of death and disease due to SARS-CoV-2 will require strategies for reinfection prevention.
2020
Long covid: Damage to multiple organs presents in young, low risk patients
Initial data from 201 patients suggest that almost 70% had impairments in one or more organs four months after their initial symptoms of SARS-CoV-2 infection.
SARS-CoV-2 infection and persistence in the human body and brain at autopsy
We show that SARS-CoV-2 is widely distributed, predominantly among patients who died with severe COVID-19, and that virus replication is present in multiple respiratory and non-respiratory tissues, including the brain, early in infection. Further, we detected persistent SARS-CoV-2 RNA in multiple anatomic sites, including throughout the brain, as late as 230 days following symptom onset in one case. Despite extensive distribution of SARS-CoV-2 RNA throughout the body, we observed little evidence of inflammation or direct viral cytopathology outside the respiratory tract. Our data indicate that in some patients SARS-CoV-2 can cause systemic infection and persist in the body for months.
​

Endothelial dysfunction in COVID-19: an overview of evidence, biomarkers, mechanisms and potential therapies

SARS-CoV-2 infection primarily affects the pulmonary system, but accumulating evidence suggests that it also affects the pan-vasculature in the extrapulmonary systems by directly (via virus infection) or indirectly (via cytokine storm), causing endothelial dysfunction (endotheliitis, endothelialitis and endotheliopathy) and multi-organ injury.
Mounting evidence suggests that SARS-CoV-2 infection leads to multiple instances of endothelial dysfunction, including reduced nitric oxide (NO) bioavailability, oxidative stress, endothelial injury, glycocalyx/barrier disruption, hyperpermeability, inflammation/leukocyte adhesion, senescence, endothelial-to-mesenchymal transition (EndoMT), hypercoagulability, thrombosis and many others. Thus, COVID-19 is deemed as a (micro)vascular and endothelial disease

Lingering cardiac involvement in previously well people after mild COVID-19

The mild but persistent non-ischemic cardiac inflammation that we describe in this study was not associated with overt structural heart disease or troponin release. Although it is triggered by a viral infection, profound myocardial injury or functional impairment is not typical, contrary to the classical definition of viral myocarditis2. Its pathophysiology is more reminiscent of findings in other chronic diffuse inflammatory syndromes that occur post-virally (for example, human immunodeficiency virus–associated cardiomyopathy)3or as a result of autoimmunity (for example, systemic lupus erythematosus4,5). In these cases, persistent subclinical cardiovascular inflammation seems to predispose people to a poor prognosis and the development of heart failure. Non-ischemic cardiac inflammatory involvement is therefore emerging as an important risk factor, and the long-term prognostic relevance of post-acute COVID-19 cardiac involvement in previously healthy people with mild initial COVID-19 illness requires further investigation.

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July 27, 2020

Outcomes of Cardiovascular Magnetic Resonance Imaging in Patients Recently Recovered From Coronavirus Disease 2019 (COVID-19)

Conclusions and Relevance In this study of a cohort of German patients recently recovered from COVID-19 infection, CMR revealed cardiac involvement in 78 patients (78%) and ongoing myocardial inflammation in 60 patients (60%), independent of preexisting conditions, severity and overall course of the acute illness, and time from the original diagnosis. These findings indicate the need for ongoing investigation of the long-term cardiovascular consequences of COVID-19.
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Post-COVID-19 Syndrome

Kamath, Vasantha; Anand, R.1; Radhakrishnan, Buvana1; Markanday, Kushal1
Post-COVID-19 “recovery” cannot be gauged solely on a negative polymerase chain reaction or hospital discharge. There is remarkable variation in the duration, severity, and fluctuation of symptoms, which can affect survivors’ quality of life, functional status, cognition, and mood, and lead to severe disability. Given the global scale of this pandemic, it is apparent that the health-care needs for patients with sequelae of COVID-19 will continue to increase for the foreseeable future.
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Immune system deviations?
We heard initial outbreaks of fungal infections of various types. Yes any infection can cause reduction in immune cells. Either because the immune system is busy diverted into tissues, fighting infection, or from apoptosis etc.
The deposits of antigens or viral pieces in many parts of the body, is perhaps causing problems, but also there appears to be markers of T cell exhaustion in some with high PD1 expression on some important immune cells too?
Long COVID following mild SARS-CoV-2 infection: characteristic T cell alterations and response to antihistamines Patients with long-COVID had reduced CD4+ and CD8+ effector memory (EM) cell numbers and increased PD-1 (programmed cell death protein 1) expression on central memory (CM) cells, whereas the asymptomatic participants had reduced CD8+ EM cells only and increased CD28 expression on CM cells. 72% of patients with long COVID who received HRA reported clinical improvement
The risk of pancreatic adenocarcinoma following SARS-CoV family infection
Our findings suggest that pancreatic adenocarcinoma is the most probably malignancy happening after infection with SARS-CoV family
The SARS-CoV-2 E protein induces Toll-like receptor 2-mediated neonatal lung injury in a model of COVID-19 viremia that is rescued by the glucocorticoid ciclesonide
This study provides insight into the pathogenesis of ALI and alveolar remodeling with SARS-CoV-2 viremia in children, whereas revealing the efficacy of steroids.
A new case-control study of Brazilian healthcare workers(HCWs) suggests as many as 27% developed long COVID after infection, and multiple infections raised the risk. The findings were published today in Infection Control & Hospital Epidemiology.
Estimates of the prevalence of long COVID, defined by the Centers for Disease Control and Prevention as new, returning, or lasting symptoms persisting 4 or more weeks after initial COVID-19 infection vary, with some studies showing as many as 43% of infected people will have some lingering symptoms 1 month after COVID-19 confirmation.
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"39 (58%) patients (with glioma) experienced tumor progression following COVID-19 infection at a median of 34 days after testing positive for COVID-19.. 22 patients had measurably increased tumor area by a median of 63%; 18 of which constituted hyperprogression; 16 patients developed multifocal disease; 8 developed new nodular enhancement; 3 developed leptomeningeal disease (LMD); and 2 experienced increased infiltrative disease alone. 10 patients’ presentation with new glioma was preceded by COVID-19 infection by a median of 31 days. GBM (glioblastoma) patients represented the majority of progression events, among whom 59% progressed within 60 days of documented infection.. Glioma patients appear to have disease progression at an accelerated pace in the first two months after COVID-19 infection."
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SARS-CoV-2 infection: The role of PD-1/PD-L1 and CTLA-4 axis
The most important diagnostic feature in individuals with COVID-19 is lymphocyte depletion, most importantly, T-cells. Due to the induction of interferon-γ (INF-γ) production by neutrophils and monocytes, which are abundantly present in the peripheral blood of the individuals with COVID-19, the expression of inhibitory immune checkpoints including, PD-1 (programmed death), PD-L1 and CTLA4 on the T-cells' surface is enhanced. The purpose of this review is to discuss the functions of these checkpoints and their effects on the dysfunction and exhaustion of T-cells, making them almost ineffective in individuals with COVID-19, especially in the cases with extreme symptoms.
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COVID-19 and renal involvement: a prospective cohort study assessing the impact of mild SARS-CoV-2 infection on the kidney function of young healthy males
Mild COVID-19 is associated with mild renal involvement without AKI. Changes in the renal function appear to be related to reduced creatinine clearance and possible albumin leakage in the acute phase of the disease. The reduction in creatinine clearance is not predicted by viral load, and it appears to be a long-term effect of the disease that can last for at least 6 months.
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Reduction and Functional Exhaustion of T Cells in Patients With Coronavirus Disease 2019 (COVID-19)
Conclusions: T cell counts are reduced significantly in COVID-19 patients, and the surviving T cells appear functionally exhausted. Non-ICU patients with total T cells counts lower than 800/μL may still require urgent intervention, even in the immediate absence of more severe symptoms due to a high risk for further deterioration in condition.
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Brain
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Cerebral blood flow in patients recovered from mild COVID-19
In this study, lower WM CBF, as well as widespread regional CBF changes identified using quantitative MRI, was found in mild COVID-19 patients. Further studies are needed to determine the reliability of this newly identified COVID-19 brain imaging marker and determine what drives these CBF changes.
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REVIEW

Alzheimer’s disease risk after COVID-19: a view from the perspective of the infectious hypothesis of neurodegeneration

Olivera, Eugenia; Sáez, Albany; Carniglia, Lila; Caruso, Carla; Lasaga, Mercedes; Durand, Daniela*
The present article aimed at reviewing the most recent literature supporting the infectious hypothesis of AD, and addressed the probable risk of developing Alzheimer-like dementia after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, based on evidence linking viral infections and amyloidosis.
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• EWS
• 10 February 2022

Heart-disease risk soars after COVID — even with a mild case

Massive study shows a long-term, substantial rise in risk of cardiovascular disease, including heart attack and stroke, after a SARS-CoV-2 infection.
JOURNAL ARTICLE

Global Prevalence of Post-Coronavirus Disease 2019 (COVID-19) Condition or Long COVID: A Meta-Analysis and Systematic Review

This study finds post-COVID-19 condition prevalence is substantial; the health effects of COVID-19 seem to be prolonged and can exert stress on the healthcare system.
Review articleBrain disorders: Impact of mild SARS-CoV-2 may shrink several parts of the brain
Coronavirus (COVID-19) is a highly infectious respiratory infection discovered in Wuhan, China, in December 2019. As a result of the pandemic, several individuals have experienced life-threatening diseases, the loss of loved ones, lockdowns, isolation, an increase in unemployment, and household conflict. Moreover, COVID-19 may cause direct brain injury via encephalopathy. The long-term impacts of this virus on mental healthand brain function need to be analysed by researchers in the coming years. This article aims to describe the prolonged neurological clinical consequences related to brain changes in people with mild COVID-19 infection. When compared to a control group, people those who tested positive for COVID-19 had more brain shrinkage, grey matter shrinkage, and tissue damage. The damage occurs predominantly in areas of the brain that are associated with odour, ambiguity, strokes, reduced attention, headaches, sensory abnormalities, depression, and mental abilities for few months after the first infection. Therefore, in patients after a severe clinical condition of COVID-19, a deepening of persistent neurological signs is necessary.
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continuing ...